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Purine Metabolism in Man: Biochemistry and Pharmacology of...

Purine Metabolism in Man: Biochemistry and Pharmacology of Uric Acid Metabolism

Oded Sperling, James B. Wyngaarden, C. Frank Starmer (auth.), Oded Sperling, Andre De Vries, James B. Wyngaarden (eds.)
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Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari­ fication.

Catégories:
Année:
1974
Edition:
1
Editeur::
Springer US
Langue:
english
Pages:
476
ISBN 10:
1475714351
ISBN 13:
9781475714357
Collection:
Advances in Experimental Medicine and Biology 41 B
Fichier:
PDF, 15.81 MB
IPFS:
CID , CID Blake2b
english, 1974
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